Absorption, Distribution, Metabolism and Excretion of Tacrolimus (FK506) in the Rat

The absorption, distribution, metabolism and excretion of tacrolimus (FK506) were studied in the rat after intravenous (i.v.) and oral administration of 14C-labeled FK506 (14C-FK506). 1. After i.v. injection at a dose level of 1.0 mg/kg, the pharmacokinetic parameters of FK506 in the whole blood were as follows: elimination ..