Humanization of an anti-human IL-6 mouse monoclonal antibody glycosylated in its heavy chain variable region

Interleukin-6 (IL-6) inhibitors are good potential therapeutic agents in human patients, and anti-IL-6antibodies are among the best candidates. Here, we have successfully humanized mouse monoclonal antibodySIQ, which specifically binds to IL-6 and strongly inhibits IL-6 functions. Since this antibody possesses Nlinkedcarbohydrates on Asn-..